Antiviral treatment selection for SARS-CoV-2 pneumonia.
Identifieur interne : 000728 ( Main/Exploration ); précédent : 000727; suivant : 000729Antiviral treatment selection for SARS-CoV-2 pneumonia.
Auteurs : Matteo Bassetti [Italie] ; Silvia Corcione [Italie] ; Silvia Dettori [Italie] ; Andrea Lombardi [Italie] ; Tommaso Lupia [Italie] ; Antonio Vena [Italie] ; Francesco Giuseppe De Rosa [Italie] ; Andrea Gori [Italie] ; Daniele Roberto Giacobbe [Italie]Source :
- Expert review of respiratory medicine [ 1747-6356 ] ; 2021.
Abstract
INTRODUCTION
Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: (
AREAS COVERED
Herein, we discuss the available evidence on the efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be considered for antiviral selection.
EXPERT OPINION
The available evidence from randomized controlled trials (RCT) currently discourages the use of lopinavir/ritonavir, hydroxychloroquine, and interferons, which did not show improved efficacy compared to standard care or placebo. Regarding remdesivir, the current body of evidence may conditionally support its use in COVID-19 patients requiring oxygen supplementation but still not requiring invasive mechanical ventilation. Finally, neutralizing monoclonal antibodies have been proven efficacious in reducing the risk of severe disease development if administered early in the course of the disease to patients at risk of progression. The results of the ongoing RCT will certainly be crucial to further improve our understanding of the optimal place in therapy of antiviral agents for COVID-19.
DOI: 10.1080/17476348.2021.1927719
PubMed: 33962524
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral treatment selection for SARS-CoV-2 pneumonia.</title><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Corcione, Silvia" sort="Corcione, Silvia" uniqKey="Corcione S" first="Silvia" last="Corcione">Silvia Corcione</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dettori, Silvia" sort="Dettori, Silvia" uniqKey="Dettori S" first="Silvia" last="Dettori">Silvia Dettori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Lombardi, Andrea" sort="Lombardi, Andrea" uniqKey="Lombardi A" first="Andrea" last="Lombardi">Andrea Lombardi</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lupia, Tommaso" sort="Lupia, Tommaso" uniqKey="Lupia T" first="Tommaso" last="Lupia">Tommaso Lupia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Vena, Antonio" sort="Vena, Antonio" uniqKey="Vena A" first="Antonio" last="Vena">Antonio Vena</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="De Rosa, Francesco Giuseppe" sort="De Rosa, Francesco Giuseppe" uniqKey="De Rosa F" first="Francesco Giuseppe" last="De Rosa">Francesco Giuseppe De Rosa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Gori, Andrea" sort="Gori, Andrea" uniqKey="Gori A" first="Andrea" last="Gori">Andrea Gori</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Giacobbe, Daniele Roberto" sort="Giacobbe, Daniele Roberto" uniqKey="Giacobbe D" first="Daniele Roberto" last="Giacobbe">Daniele Roberto Giacobbe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33962524</idno><idno type="pmid">33962524</idno><idno type="doi">10.1080/17476348.2021.1927719</idno><idno type="wicri:Area/Main/Corpus">000042</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000042</idno><idno type="wicri:Area/Main/Curation">000042</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000042</idno><idno type="wicri:Area/Main/Exploration">000042</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiviral treatment selection for SARS-CoV-2 pneumonia.</title><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Corcione, Silvia" sort="Corcione, Silvia" uniqKey="Corcione S" first="Silvia" last="Corcione">Silvia Corcione</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dettori, Silvia" sort="Dettori, Silvia" uniqKey="Dettori S" first="Silvia" last="Dettori">Silvia Dettori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Lombardi, Andrea" sort="Lombardi, Andrea" uniqKey="Lombardi A" first="Andrea" last="Lombardi">Andrea Lombardi</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lupia, Tommaso" sort="Lupia, Tommaso" uniqKey="Lupia T" first="Tommaso" last="Lupia">Tommaso Lupia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Vena, Antonio" sort="Vena, Antonio" uniqKey="Vena A" first="Antonio" last="Vena">Antonio Vena</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="De Rosa, Francesco Giuseppe" sort="De Rosa, Francesco Giuseppe" uniqKey="De Rosa F" first="Francesco Giuseppe" last="De Rosa">Francesco Giuseppe De Rosa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Gori, Andrea" sort="Gori, Andrea" uniqKey="Gori A" first="Andrea" last="Gori">Andrea Gori</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathophysiology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Giacobbe, Daniele Roberto" sort="Giacobbe, Daniele Roberto" uniqKey="Giacobbe D" first="Daniele Roberto" last="Giacobbe">Daniele Roberto Giacobbe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of respiratory medicine</title><idno type="eISSN">1747-6356</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: (</p></div><div type="abstract" xml:lang="en"><p><b>AREAS COVERED</b></p><p>Herein, we discuss the available evidence on the efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be considered for antiviral selection.</p></div><div type="abstract" xml:lang="en"><p><b>EXPERT OPINION</b></p><p>The available evidence from randomized controlled trials (RCT) currently discourages the use of lopinavir/ritonavir, hydroxychloroquine, and interferons, which did not show improved efficacy compared to standard care or placebo. Regarding remdesivir, the current body of evidence may conditionally support its use in COVID-19 patients requiring oxygen supplementation but still not requiring invasive mechanical ventilation. Finally, neutralizing monoclonal antibodies have been proven efficacious in reducing the risk of severe disease development if administered early in the course of the disease to patients at risk of progression. The results of the ongoing RCT will certainly be crucial to further improve our understanding of the optimal place in therapy of antiviral agents for COVID-19.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33962524</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1747-6356</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>May</Month><Day>21</Day></PubDate></JournalIssue><Title>Expert review of respiratory medicine</Title><ISOAbbreviation>Expert Rev Respir Med</ISOAbbreviation></Journal><ArticleTitle>Antiviral treatment selection for SARS-CoV-2 pneumonia.</ArticleTitle><Pagination><MedlinePgn>1-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/17476348.2021.1927719</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="UNASSIGNED">Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: (<i>i</i>) the damage caused by the virus (with antivirals); (<i>ii</i>) the damage caused by a dysregulated host response (with immunomodulatory agents).</AbstractText><AbstractText Label="AREAS COVERED" NlmCategory="UNASSIGNED">Herein, we discuss the available evidence on the efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be considered for antiviral selection.</AbstractText><AbstractText Label="EXPERT OPINION" NlmCategory="UNASSIGNED">The available evidence from randomized controlled trials (RCT) currently discourages the use of lopinavir/ritonavir, hydroxychloroquine, and interferons, which did not show improved efficacy compared to standard care or placebo. Regarding remdesivir, the current body of evidence may conditionally support its use in COVID-19 patients requiring oxygen supplementation but still not requiring invasive mechanical ventilation. Finally, neutralizing monoclonal antibodies have been proven efficacious in reducing the risk of severe disease development if administered early in the course of the disease to patients at risk of progression. The results of the ongoing RCT will certainly be crucial to further improve our understanding of the optimal place in therapy of antiviral agents for COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bassetti</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0145-9740</Identifier><AffiliationInfo><Affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corcione</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dettori</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lombardi</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lupia</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vena</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Rosa</LastName><ForeName>Francesco Giuseppe</ForeName><Initials>FG</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gori</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giacobbe</LastName><ForeName>Daniele Roberto</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Department of Health Sciences, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS, Genoa, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>05</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Rev Respir Med</MedlineTA><NlmUniqueID>101278196</NlmUniqueID><ISSNLinking>1747-6348</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">antiviral</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">lopinavir/ritonavir</Keyword><Keyword MajorTopicYN="N">remdesivir</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>5</Month><Day>8</Day><Hour>5</Hour><Minute>36</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33962524</ArticleId><ArticleId IdType="doi">10.1080/17476348.2021.1927719</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li><li>Piémont</li></region><settlement><li>Milan</li><li>Turin</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><name sortKey="Corcione, Silvia" sort="Corcione, Silvia" uniqKey="Corcione S" first="Silvia" last="Corcione">Silvia Corcione</name><name sortKey="De Rosa, Francesco Giuseppe" sort="De Rosa, Francesco Giuseppe" uniqKey="De Rosa F" first="Francesco Giuseppe" last="De Rosa">Francesco Giuseppe De Rosa</name><name sortKey="Dettori, Silvia" sort="Dettori, Silvia" uniqKey="Dettori S" first="Silvia" last="Dettori">Silvia Dettori</name><name sortKey="Dettori, Silvia" sort="Dettori, Silvia" uniqKey="Dettori S" first="Silvia" last="Dettori">Silvia Dettori</name><name sortKey="Giacobbe, Daniele Roberto" sort="Giacobbe, Daniele Roberto" uniqKey="Giacobbe D" first="Daniele Roberto" last="Giacobbe">Daniele Roberto Giacobbe</name><name sortKey="Giacobbe, Daniele Roberto" sort="Giacobbe, Daniele Roberto" uniqKey="Giacobbe D" first="Daniele Roberto" last="Giacobbe">Daniele Roberto Giacobbe</name><name sortKey="Gori, Andrea" sort="Gori, Andrea" uniqKey="Gori A" first="Andrea" last="Gori">Andrea Gori</name><name sortKey="Gori, Andrea" sort="Gori, Andrea" uniqKey="Gori A" first="Andrea" last="Gori">Andrea Gori</name><name sortKey="Gori, Andrea" sort="Gori, Andrea" uniqKey="Gori A" first="Andrea" last="Gori">Andrea Gori</name><name sortKey="Lombardi, Andrea" sort="Lombardi, Andrea" uniqKey="Lombardi A" first="Andrea" last="Lombardi">Andrea Lombardi</name><name sortKey="Lombardi, Andrea" sort="Lombardi, Andrea" uniqKey="Lombardi A" first="Andrea" last="Lombardi">Andrea Lombardi</name><name sortKey="Lupia, Tommaso" sort="Lupia, Tommaso" uniqKey="Lupia T" first="Tommaso" last="Lupia">Tommaso Lupia</name><name sortKey="Vena, Antonio" sort="Vena, Antonio" uniqKey="Vena A" first="Antonio" last="Vena">Antonio Vena</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000728 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000728 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33962524
|texte= Antiviral treatment selection for SARS-CoV-2 pneumonia.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33962524" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |